I was experiencing problems openening the “Datasheet View” of a SharePoint list. In my case, the issue was that ActiveX components where not allowed to run in the browser due to some security settings. While googling to find this solution I found some other things that might have caused the problem. Here they are:
- The browser is too old: IE 5.01 with SP2 is required
- The “Microsoft Office Access Web Datasheet Component” is not installed. This is included in Office 2007 and also available on the Office 2003 installation disc

